Dry Ice Compaction in Piston Extrusion Process

Compaction of montmorillonite in ultra-dry state

The current study discovers that uniaxial compression under ambient condition can directly cause strong bonding in ultra-dry montmorillonite, which is attributed to the secondary molecular interaction other than hydrogen bonding. The strength of so-processed material is sensitive to the lateral confinement condition of loading. Similar compaction pressure produces equally strong solids between ...

BIOLOGICAL SCIENCES: Biophysics and Computational Biology Mitotic chromosome compaction via active loop extrusion Short title: Chromosome compaction via loop extrusion

During cell division chromosomes are compacted in length by more than a hundred-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ~100Kb loops. The mechanism underlying the active process of chromosome compaction into a stack of loops is unknown. Here we test the hypothesis that chromosomes are compacte...

1 Powder Compaction by Dry Pressing

Compaction and segregation of sister chromatids via active loop extrusion

The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle chromosomes, arriving at individualized chromatids with morphology observed in vivo. Our model res...

Optimization of Roll Compaction/Dry Granulation (Rcdg) Process for Poorly Flowable Antiviral Formulation

In this investigation, roll compaction/dry granulation (RCDG) process was optimized for formulation of model amorphous drug candidate with fine-fluffy nature and poor flowability. Three operating parameters the roller speed, the hydraulic pressure and the granulator speed on the Alexanderwerk WP 120 Pharma Roll Compactor were varied. The planned response variable for study was % retention over ...